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Current Developments in the Stable Production of Human Induced Pluripotent Stem Cells Review

Ikki Horiguchi, Masahiro Kino-oka

Engineering 2021, Volume 7, Issue 2, Pages 144-152 doi: 10.1016/j.eng.2021.01.001

Abstract:

Induced pluripotent stem cells (iPSCs) are considered to be ideal and promising cell sources for variousprocess, such as filling and freezing processes, which limit the production scale due to decreased cellthat multidisciplinary investigations are essential to understand the different factors that influence cell

Keywords： Induced pluripotent stem cell Cell manufacturing Expansion Filling Freezing

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Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation

Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 429-441 doi: 10.1007/s11684-021-0842-9

Abstract: The local microenvironment is essential to stem cell-based therapy for ischemic stroke, and spatiotemporalinvestigate the microenvironmental changes in the subacute and chronic phases of ischemic stroke after stemcell transplantation.Herein, induced pluripotent stem cells (iPSCs) and neural stem cells (NSCs) were transplanted into thetests were applied to evaluate the metabolic and neurofunctional alterations of rats transplanted with stem

Keywords： ischemic stroke microenvironment induced pluripotent stem cells (iPSCs) positron emission tomography

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Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity

Chuanfeng Wu, Cynthia E. Dunbar

Frontiers of Medicine 2011, Volume 5, Issue 4, Pages 356-371 doi: 10.1007/s11684-011-0159-1

Abstract: Virus-based vectors are widely used in hematopoietic stem cell (HSC) gene therapy, and have the abilityreview will summarize current information on the mechanisms of insertional mutagenesis in hematopoietic stem

Keywords： gene therapy hematopoietic stem cells insertional mutagenesis genotoxicity induced pluripotent stem cell

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The past, present and future of bovine pluripotent stem cells: a brief overview

Xiuchun TIAN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1, Pages 3-7 doi: 10.15302/J-FASE-2018247

Abstract: of gene-targeting, true pluripotent stem cells in this economically important species are still elusiverapid advances in genome-editing and cloning using homologously recombined somatic cells, the need for pluripotentstem cells for precise genetic modification in any species became questionable.uniqueness of the pluripotency circuitry across mammalian species may be the main objective for studying pluripotentstem cells in the bovine.

Keywords： bovine embryonic induced pluripotent stem cells

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Progress, problems and prospects of porcine pluripotent stem cells

Hanning WANG,Yangli PEI,Ning LI,Jianyong HAN

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 1, Pages 6-15 doi: 10.15302/J-FASE-2014009

Abstract: Pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced PSCs (iPSCs), can differentiate

Keywords： induced pluripotent stem cells embryonic stem cells pig reprogramming

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Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1, Pages 8-27 doi: 10.15302/J-FASE-2018233

Abstract:

Pluripotent stem cells (PSCs) are characterized by their capacity for high self-renewal and multipledifferentiation potential and include embryonic stem cells, embryonic germ cells and induced PSCs.

Keywords： embryonic germ cells embryonic stem cells induced pluripotent stem cells pigs pluripotent stem cells

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Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism

Frontiers of Medicine 2022, Volume 16, Issue 6, Pages 827-858 doi: 10.1007/s11684-022-0948-8

Abstract: Besides routine therapeutic methods, stem cells are rapidly being examined as viable alternative therapiesRemarkable progress has been made in understanding the biology and purpose of stem cells.The affected pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs) are further studied fortheir possible use in reproductive medicine, particularly for infertility induced by premature ovarianthis study discusses current developments in the use of some kinds of MSCs such as adipose-derived stem

Keywords： infertility stem cell therapy mesenchymal stem cells pluripotent stem cells

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Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

Qijing LEI, Qin PAN, Shuai YU, Na LI, Shulin CHEN, Kuldip SIDHU, Jinlian HUA

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1, Pages 28-32 doi: 10.15302/J-FASE-2018222

Abstract: However, PGCs can be converted into the pluripotent state by first dedifferentiation to embryonic germcells and then by reprogramming to induce them to become pluripotent stem cells (iPSCs).Here, we discuss recent advances in the stem cell field for obtaining iPSCs from PGCs.

Keywords： pig pluripotent stem cells primordial germ cells reprogramming

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Induced pluripotent stem cells (IPS): current situation and prospect

Han Weidong,Zhao Yali,Fu Xiaobing

Strategic Study of CAE 2009, Volume 11, Issue 5, Pages 81-87

Abstract:

Differentiated somatic cells can be reprogrammed into induced pluripotentstem cells (iPS) by transduction of a defined transcription factors.Undoubtedly, iPS-cell technology is a great breakthrough of stem cell research field in recent years.However, the present development of pluripotent cells from individual somatic cells just opened up anew door to stem cell research world, much work remains to be done before iPS cells can be considered

Keywords： somatic cells reprogramming iPS cells

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The unregulated commercialization of stem cell treatments: a global perspective

Douglas Sipp

Frontiers of Medicine 2011, Volume 5, Issue 4, Pages 348-355 doi: 10.1007/s11684-011-0150-x

Abstract: Research into the biological properties and clinical potential of stem cells has spurred strong publicof demonstrated safety and efficacy have been developed with the exception of uses of hematopoietic stembasis notwithstanding, hundreds of companies and private clinics around the world now sell putative stemcell treatments for an enormously broad range of medical and quality-of-life conditions.In this review, I provide an overview of the global industry in pseudomedical stem cell treatments, with

Keywords： stem cell tourism medical ethics stem cell policy and regulation alternative medicine

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The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 190-200 doi: 10.1007/s11684-014-0323-5

Abstract:

Over the past few years, several new achievements have been made from stem cell studies, many of whichMoreover, some stem cell-based products have been approved for marketing by different national regulatoryHowever, many critical issues associated mainly with incomplete understanding of stem cell biology andcell regulatory sciences with a goal of promoting the steadfast growth of the well-regulated stem celltherapies abreast of evolvement of stem cell sciences and technologies.

Keywords： stem cell-based medicinal products (SCMPs) stem cell therapy (SCT) safety effectiveness standards guidelines

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Therapeutic potential of stem cell in liver regeneration

Jinzheng LI, Min LI, Bolin NIU, Jianping GONG

Frontiers of Medicine 2011, Volume 5, Issue 1, Pages 26-32 doi: 10.1007/s11684-011-0107-0

Abstract: Stem cell therapy, with the ability for self-renewal and potential for multilineage differentiation,cells derived from multipotent stem cells leads to donor cell-mediated repopulation of the liver andHowever, a registered clinical application based on stem cell technology will take at least an additional5 to 10 years because of some limitations; e.g. the lack of suitable cell sources and risk of teratomaThis review summarizes the general understanding of the therapeutic potentials of stem cells in liver

Keywords： stem cell liver disease regenerative medicine

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Stem cell niches and endogenous electric fields in tissue repair

Li LI, Jianxin JIANG

Frontiers of Medicine 2011, Volume 5, Issue 1, Pages 40-44 doi: 10.1007/s11684-011-0108-z

Abstract:

Adult stem cells are responsible for homeostasis and repair of many tissues.Endogenous adult stem cells reside in certain regions of organs, known as the stem cell niche, whichMany regulatory factors are involved in the stem cell-based repair process, including stem cell nichesHere we briefly review the role of stem cell niches and endogenous electric fields in tissue repair,and hypothesize that endogenous electric fields become part of stem cell niche in the wound site.

Keywords： stem cell stem cell niche electric field tissue repair

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SALL4 maintains self-renewal of porcine pluripotent stem cells through downregulation of OTX2

Ning WANG, Sile WANG, Yaxian WANG, Yuanxing CAI, Fan YANG, Huayan WANG

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1, Pages 81-92 doi: 10.15302/J-FASE-2017180

Abstract: alternative splicing variants, which are differentially expressed and has a key role in maintaining pluripotentstem cells.However, the molecular features and function of SALL4 have not been well elucidated in porcine inducedpluripotent stem cells (piPSCs).Overexpression of SALL4A and SALL4B in PEF cells could significantly stimulated expression of endogenous pluripotent

Keywords： OTX2 pluripotency pig SALL4 transcription regulation

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Transcriptomics and proteomics in stem cell research

Hai Wang,Qian Zhang,Xiangdong Fang

Frontiers of Medicine 2014, Volume 8, Issue 4, Pages 433-444 doi: 10.1007/s11684-014-0336-0

Abstract:

Stem cells are capable of self-renewal and differentiation, and the processes regulating these eventsIn particular, the molecular mechanisms of the self-renewal, proliferation, and differentiation of stemcell biology.and proteomic characterization of the different stem cell processes.cell biology and promote the clinical applications of stem cells.

Keywords： embryonic stem cells transcriptomics proteomics